A) E-Box

The E-box is a stack monitor developed by the Shanghai Guifan Digital Technology Co. Ltd in Shanghai China. As currently designed it was developed for intermittent regimens of individual drugs and would require several different packaged regimens in the supply lines to suit patients of different weight. It currently does not use fixed dose combinations of pills.
B) U-box Carousel Monitor
A group at the Massachusetts Institute of Technology have developed a portable medication monitor shown in the following image

 It is 4.75 inches in diameter and 1.5 inches tall. It is designed for the intermittent regimens used in India. As detailed in the section Requirements for Optimal Medication Monitors for TB Medications.  We believe intermittent treatment should not be used with medication monitors. If the U-box were redesigned for a month’s supply of medication given daily, the device would be much larger.
 For more details regarding the device contact. manish@innovatorsinhealth.org  or look at website http://www.innovatorsinhealth.org/solutions/pillbox.shtml
TITLE PAGE and ABSTRACT

 Background and Optimal Requirements for Medication Monitors for TB Treatment

 I.   Cover and Cap Opening Monitors
II.  Dose Removal Monitors

 A) Stack Monitor for Packaged Medication  
         As of July 2010 we believe this will prove to be the most practical Medication Monitor
B) Strip Package Monitor
C) Clip Monitor for WHO's Packaged Medication
D) Multi-compartment Monitor
E) Trace Sheet Monitors
F) Alternate Means for Providing Moisture Protection

III. Dose Removal Monitors Developed by Other Groups
     A) E-box

      B) U-box
IV. Devices That Prove or Come Close to Proving Medication Ingestion
A) X Out TB
B) Necklace Monitor
C) Fluorescent Pill Wrist Watch Monitor (In development)  
D) Networked Pill
E) E-Tect
F) Video Phone to Monitor DOT

 V. Display incorporated into the monitor

VI. Means to instruct and remind the patient

VII. Retrieval of the adherence record
A) Direct Communication with Computers

B) Using a Dot Matrix Display to determine the battery status
C) Using a Dot Matrix display to retrieve the adherence record
D) Using a single red/green LED for summary adherence record and battery status
E) Use of 2-digit display for reviewing battery status and adherence record
F) Communicating by Mobile Phones

 VIII. Retrieval of clinical data stored in the monitor
IX. Further notes on information retrieval
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Adapting to New International TB Treatment Standards with Medication Monitors and DOT given selectively